Temafloxacin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

替马沙星是一种抗生素和抗分枝杆菌剂。它用于治疗下呼吸道感染、生殖器和泌尿道感染（如前列腺炎）和皮肤感染。

Temafloxacin is an antibiotic and antimycobacterial agent. It used to treat lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.(In Vitro):Temafloxacin has broad antimicrobial activity against gram-positive and gram-negative bacteria, including improved in vitro activity against?Streptococcus pneumonia,?Mycoplasma hominis, and anaerobic bacteria, including?Bacteroides fragilis.(In Vivo):Temafloxacin has a half-life of 7-8 hours and rapid gastrointestinal absorption. Temafloxacin has excellent tissue and body fluid penetration and concentration except for the central nervous system (CNS).

Temafloxacin (0-64 μg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 μg/mL for E. coli, P. aeruginosa, and S. aureus, respectively. Cell Viability AssayCell Line:E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains).Concentration:0-64 μg/mLIncubation Time:18-24 hResult:Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 μg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: μg/mL).

Temafloxacin (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis.Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS)). Animal Model:Female CF-1 mice (20-25 g) (murine pyelonephritis model).Dosage:6.25, 25, 100 mg/kg Administration:Orally; single.Result:Reduced the number of viable bacteria in the kidneys of mice.Animal Model:Female CF-1 mice (20-25 g).Dosage:100 mg/kg Administration:Subcutaneously or orally; single.Result:Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice.

Omniflox

Microbiology/Virology

Antibiotic

Human Endogenous Metabolite

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108319-06-8

417.388

C21H18F3N3O3

>98% (HPLC)

In Vitro:?DMSO : < 1 mg/mL (insoluble)

CC1CN(CCN1)c1cc2n(cc(C(O)=O)c(=O)c2cc1F)-c1ccc(F)cc1F

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(-20℃)

With Ice Pack

≥ 2 years