TRi-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TRi-1 是胞质硫氧还蛋白还原酶 1 (TXNRD1) 的不可逆抑制剂，IC50 为 12 nM。 TRi-1对于抗癌治疗来说线粒体毒性很小。

TRi-1 is irreversible inhibitor of?cytosolic thioredoxin reductase 1 (TXNRD1) with an?IC50?of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.

Western Blot Analysis Cell Line:FaDu cellsConcentration:0.679 and 6.79 μM Incubation Time:6 hResult:Efficiently activated JNK and p38 phosphorylation. Cell Cytotoxicity Assay Cell Line:Leukemia, non-small cell lung, CNS, colon, melanoma, ovarian, renal, prostate and breast cancer cells Concentration:10 nM-100 μM Incubation Time:48 h Result:Displayed potency against every cell line tested, with an average growth inhibition to 50% (GI50) of 6.31 μM.

Animal Model:SCID mice bearing established human FaDu cell xenograftsDosage:10 mg/kg Administration:Intravenous injection, twice a day for 4 days Result:Resulted in decreased tumor growth compared to vehicle controls within four days with no signs of overt toxicity or changes in mouse weight relative to vehicle control.Animal Model:PyMT-MMTV mice that spontaneously develop malignant breast cancer tumors.Dosage:5 mg/kg Administration: Intraperitoneal injection, twice a week for 3 weeks Result:Impaired tumor growth, significantly reduced tumor volumes.

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Others

Other Targets

TXNRD1

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246020-68-8

328.72

C12H9ClN2O5S

>98% (HPLC)

DMSO:62.5 mg/mL?(190.13 mM)

COc1ccc(c(n1)S(=O)(=O)c1ccc(Cl)cc1)[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years