TGN020

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TGN-020 是水通道蛋白 4 (AQP4，IC50：3.1 μM) 的抑制剂，水通道蛋白 4 是大脑中最丰富的水通道。

TGN-020 is an inhibitor of Aquaporin 4 (AQP4 IC50: 3.1 μM) the most abundant water channel in the brain.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.(In Vivo):TGN-020 (0.02 mg/μL; two microliter intravitreal injections) can suppress retinal edema in STZ-induced diabetic rats (nine-week-old male Wistar rats) retinas.TGN-020 (100?mg/kg; ip; single dose immediately followed SCI) promotes functional recovery at days 3, 7, 14, 21, and 28, as well as reduces the degree of edema and inhibits the expression of AQP4, GFAP, PCNA at days 3 after SCI. TGN-020 inhibits the glial scar formation and upregulates GAP-43 expression in adult female Sprague-Dawley rats (180-220?g, 9-10?weeks old) with SCI.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They are for reference only.

TGN-020 (0.02 mg/μL; two microliter intravitreal injections) can suppress retinal edema in STZ-induced diabetic rats (nine-week-old male Wistar rats) retinas.TGN-020 (100?mg/kg; ip; single dose immediately followed SCI) promotes functional recovery at days 3, 7, 14, 21, and 28, as well as reduces the degree of edema and inhibits the expression of AQP4, GFAP, PCNA at days 3 after SCI. TGN-020 inhibits the glial scar formation and upregulates GAP-43 expression in adult female Sprague-Dawley rats (180-220?g, 9-10?weeks old) with SCI.

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Others

Other Targets

AQP4

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51987-99-6

206.22

C8H6N4OS

>98% (HPLC)

DMSO: 8 mg/mL

O=C(Nc1nncs1)c1cccnc1

N-134-Thiadiazol-2-yl-3-pyridinecarboxamide

(-20℃)

With Ice Pack

≥ 2 years