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Synucleozid hydrochloride

CAS No. 2741856-68-6

Synucleozid hydrochloride ( —— )

产品货号. M33133 CAS No. 2741856-68-6

Synucleozid (NSC 377363) 是可编码 α-突触核蛋白的 SNCA?mRNA 的有效抑制剂。Synucleozid 选择性靶向?α-synuclein?mRNA 的 5'UTR的 IRE 位点,减少了加载到多核糖体中的?SNCA?mRNA 的量,从而抑制了α-synuclein 蛋白的翻译。Synucleozid 有潜力用于帕金森病的相关研究。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥2558 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Synucleozid hydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Synucleozid (NSC 377363) 是可编码 α-突触核蛋白的 SNCA?mRNA 的有效抑制剂。Synucleozid 选择性靶向?α-synuclein?mRNA 的 5'UTR的 IRE 位点,减少了加载到多核糖体中的?SNCA?mRNA 的量,从而抑制了α-synuclein 蛋白的翻译。Synucleozid 有潜力用于帕金森病的相关研究。
  • 产品描述
    Synucleozid hydrochloride (NSC 377363 hydrochloride) is a potent inhibitor of the?SNCA?mRNA?that encodes α-synuclein protein. Synucleozid selectively?targets the?α-synuclein?mRNA 5′ UTR at the designed IRE site, decreases the amount of?SNCA?mRNA loaded into polysomes and thereby inhibits?SNCA?translation. Synucleozid has the potential for the investigation of Parkinson’s disease.
  • 体外实验
    Synucleozid (0.25-1 μM; 24 hours) abrogates cytotoxicity induced by α-synuclein preformed fibrils, which act as seeds and recruit endogenous α-synuclein to aggregate.Synucleozid (0-1 μM; 24 hours) binds to the A bulge near the base of the IRE hairpin, reduced levels of α-synuclein in a dose-dependent manner with an IC50 of 500 nM, and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells.Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities. It decreases 2-AP emission with an EC50?value of 2.7 ± 0.4 μM, recovery of 2-AP emissions is observed as a function of unlabeled?SNCA?IRE RNA (RNA-0) concentration, affording a competitive?Kd?of 1.5 ± 0.3 μM.Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins that have IREs in their mRNA’s UTR including APP, PrP, Ferritin and TfR as a dose-dependent mannner. All panels is completed in SH-SY5Y cells, except for PrP protein which is assessed in Neuro-2A cells.Cell Viability Assay Cell Line:SH-SY5Y neuroblastoma cells Concentration:0.25 μM, 0.5 μM, 1 μM Incubation Time:24 hours Result:Decreased LDH release as a dose-dependent manner.Western Blot Analysis Cell Line:SH-SY5Y neuroblastoma cells Concentration:0.25 μM, 0.5 μM, 1 μM Incubation Time:24 hours Result:Decreased α-synuclein expression as a concentration-dependent manner.
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Cell Cycle/DNA Damage
  • 靶点
    DNA/RNA Synthesis
  • 受体
    DNA/RNA Synthesis
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2741856-68-6
  • 分子量
    404.9
  • 分子式
    C22H21ClN6
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO 中的溶解度 : 125 mg/mL (308.72 mM; 超声助溶 ) H2O 中的溶解度 : 2 mg/mL (4.94 mM; 超声助溶)
  • SMILES
    Cl.N=C(N)C1=CC=C(C=C1)NC=2C=CC(=CC2)C3=CC4=CC=C(C=C4N3)C(=N)N
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.?
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