Solamargine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Solamargine 是从中药 Solanum nigrum L. (SNL) 中提取的主要甾体生物碱苷；已被证明可以抑制多种癌细胞的生长并诱导其凋亡。

Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.

Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis.Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC50s are 9.21 and 19.88 μg/ml, respectively. Cell Viability Assay Cell Line:SMMC-7721cells Concentration:15 μg/ml.Incubation Time:72 hours Result:Displayed a significant increase of sub-G1.

Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo. Animal Model:Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old) Dosage:10 mg/kg Administration:Intragastric administration; once daily for 8 days Result:Tumor growth was significantly inhibited .

Solamargin | δ-Solanigrine

Angiogenesis

PKC

p38 MAPK| STAT3

Cancer

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20311-51-7

868.07

C45H73NO15

>98% (HPLC)

DMSO : ≥ 8.8 mg/mL; 10.14 mM

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(-20℃)

With Ice Pack

≥ 2 years