
Sitafloxacin
CAS No. 127254-12-0
Sitafloxacin ( —— )
产品货号. M35721 CAS No. 127254-12-0
Sitafloxacin (DU-6859a) 是一种有效的口服活性氟喹诺酮类抗生素。 Sitafloxacin 对广泛的革兰氏阳性和革兰氏阴性细菌 (包括厌氧菌) 以及非典型病原体具有抗菌活性。Sitafloxacin 可用于呼吸道感染和尿路感染的研究。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1576 | 有现货 |
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5MG | ¥2390 | 有现货 |
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10MG | ¥4643 | 有现货 |
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25MG | ¥9384 | 有现货 |
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50MG | ¥17595 | 有现货 |
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100MG | ¥22721 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Sitafloxacin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Sitafloxacin (DU-6859a) 是一种有效的口服活性氟喹诺酮类抗生素。 Sitafloxacin 对广泛的革兰氏阳性和革兰氏阴性细菌 (包括厌氧菌) 以及非典型病原体具有抗菌活性。Sitafloxacin 可用于呼吸道感染和尿路感染的研究。
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产品描述Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection.
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体外实验Sitafloxacin (DU6859a) shows antibacterial activities with MIC of 0.03, 0.12, 0.06 mg/L for wild-type ATCC 49619, gyrA mutant SP39, parCmutant 1026523 streptococcus pneumoniae stran, respectively. Sitafloxacin (DU6859a) shows antibacterial activities for quinolone-susceptible strains of streptococcus pneumoniae with MIC of 0.03, 0.03 mg/L for EG 00093 and EG 00218 strain, respectively.Sitafloxacin (DU6859a) shows inhibition for DNA gyrase and topoisomerase IV (TopoIV) with >IC50s of 4.38, 3.12 mg/L, respectively.
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体内实验Sitafloxacin (DU-6859a) (12.5-100 mg/kg; i.g.; daily for 4 weeks; BALB/c female mice) has antibacterial activity. M. ulcerans cells could be isolated from the inoculated footpads and there was no evidence of footpad swelling.Animal Model:BALB/c female mice Dosage:12.5, 25, 50 and 100 mg/kg Administration:Oral gavage; daily, for 4 weeks Result:Inhibits the growth of Mycobacterium ulcerans and the M. ulcerans cells.
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同义词——
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通路Microbiology/Virology
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靶点Antibiotic
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受体Antibiotic
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研究领域——
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适应症——
化学信息
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CAS Number127254-12-0
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分子量409.81
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分子式C19H18ClF2N3O3
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纯度>98% (HPLC)
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溶解度——
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SMILESN[C@H]1C2(CN(C1)C=3C(Cl)=C4N(C=C(C(O)=O)C(=O)C4=CC3F)[C@H]5[C@@H](F)C5)CC2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Okumura R, et al. Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae. J Antimicrob Chemother. 2008 Jul;62(1):98-104.?
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