• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Sitafloxacin

CAS No. 127254-12-0

Sitafloxacin ( —— )

产品货号. M35721 CAS No. 127254-12-0

Sitafloxacin (DU-6859a) 是一种有效的口服活性氟喹诺酮类抗生素。 Sitafloxacin 对广泛的革兰氏阳性和革兰氏阴性细菌 (包括厌氧菌) 以及非典型病原体具有抗菌活性。Sitafloxacin 可用于呼吸道感染和尿路感染的研究。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥1576 有现货
5MG ¥2390 有现货
10MG ¥4643 有现货
25MG ¥9384 有现货
50MG ¥17595 有现货
100MG ¥22721 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Sitafloxacin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Sitafloxacin (DU-6859a) 是一种有效的口服活性氟喹诺酮类抗生素。 Sitafloxacin 对广泛的革兰氏阳性和革兰氏阴性细菌 (包括厌氧菌) 以及非典型病原体具有抗菌活性。Sitafloxacin 可用于呼吸道感染和尿路感染的研究。
  • 产品描述
    Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection.
  • 体外实验
    Sitafloxacin (DU6859a) shows antibacterial activities with MIC of 0.03, 0.12, 0.06 mg/L for wild-type ATCC 49619, gyrA mutant SP39, parCmutant 1026523 streptococcus pneumoniae stran, respectively. Sitafloxacin (DU6859a) shows antibacterial activities for quinolone-susceptible strains of streptococcus pneumoniae with MIC of 0.03, 0.03 mg/L for EG 00093 and EG 00218 strain, respectively.Sitafloxacin (DU6859a) shows inhibition for DNA gyrase and topoisomerase IV (TopoIV) with >IC50s of 4.38, 3.12 mg/L, respectively.
  • 体内实验
    Sitafloxacin (DU-6859a) (12.5-100 mg/kg; i.g.; daily for 4 weeks; BALB/c female mice) has antibacterial activity. M. ulcerans cells could be isolated from the inoculated footpads and there was no evidence of footpad swelling.Animal Model:BALB/c female mice Dosage:12.5, 25, 50 and 100 mg/kg Administration:Oral gavage; daily, for 4 weeks Result:Inhibits the growth of Mycobacterium ulcerans and the M. ulcerans cells.
  • 同义词
    ——
  • 通路
    Microbiology/Virology
  • 靶点
    Antibiotic
  • 受体
    Antibiotic
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    127254-12-0
  • 分子量
    409.81
  • 分子式
    C19H18ClF2N3O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    N[C@H]1C2(CN(C1)C=3C(Cl)=C4N(C=C(C(O)=O)C(=O)C4=CC3F)[C@H]5[C@@H](F)C5)CC2
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Okumura R, et al. Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae. J Antimicrob Chemother. 2008 Jul;62(1):98-104.?
产品手册
关联产品
  • (S)-GNA-T-phosphoram...

    (S)-GNA-T-phosphoramidite is a nucleoside analog commonly used in the synthesis of other active compounds.

  • Tilmicosin phosphate

    磷酸替米考星是一种大环内酯类抗生素,用于治疗牛体内引起牛呼吸道疾病的病原体。

  • Cefazaflur

    Cefazaflur is a novel semi-synthetic cephalosporin derivative that can be used as an Antibiotic agent.