Sinefungin ( Adenosyl-Ornithine | A-9145 | Antibiotic 32232RP )

产品货号. M24582 CAS No. 58944-73-3

Sinefungin 是病毒体 mRNA(鸟嘌呤-7-)-甲基转移酶、mRNA(核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥2535	有现货
50MG	￥15066	有现货
100MG	￥26487	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Sinefungin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Sinefungin 是病毒体 mRNA(鸟嘌呤-7-)-甲基转移酶、mRNA(核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。
产品描述

Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.
体外实验

Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells. Western Blot Analysis Cell Line:Renal epithelial cells.Concentration:0.5 or 1.0 μg/mL.Incubation Time:Pretreatment 60 minutes before TGF-β1 (10 ng/mL).Result:Significantly reduced TGF-β1-inducedα-SMA protein expression and inhibited H3K4me1 in a dose-dependent manner in both NRK-52E and NRK-49F cells.
体内实验

Sinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy. Animal Model:Male C57BL/6J mice (8 weeks of age).Dosage:10 mg/kg Administration:Administered intraperitoneally per day immediately after UUO (prepared as a suspension in distilled water and 0.9% NaCl solution).Result:Inhibited α-SMA protein expression.Ameliorated those (α-SMA, FSP-1, collagen 1, collagen 3) both at 3 and 7 days after UUO.
同义词

Adenosyl-Ornithine | A-9145 | Antibiotic 32232RP
通路

Others
靶点

Other Targets
受体

SET7/9
研究领域

——
适应症

——

化学信息

CAS Number

58944-73-3
分子量

381.39
分子式

C15H23N7O5
纯度

>98% (HPLC)
溶解度

H2O:95 mg/mL (249.09 mM; Need ultrasonic)
SMILES

N[C@H](CC[C@H](C(O)=O)N)C[C@@H]([C@@H]([C@@H]1O)O)O[C@@H]1n1c2ncnc(N)c2nc1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7.

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