Savolitinib

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Savolitinib (AZD-6094) 是一种有效的、高选择性的、口服生物可利用的 c-Met 抑制剂，对于 c-Met 和 p-Met 的 IC50 值分别为 5 nM 和 3 nM。

Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity.

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Animal Model:U87MG xenograft model in athymic nude mice Dosage:1 mg/kg, 2.5 mg/kg and 10.0 mg/kg Administration:Oral administration; daily; for 21 days Result:Demonstrated dose-dependent tumor growth inhibition in a U87MG subcutaneous xenograft model.

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Angiogenesis

c-Met/HGFR

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1313725-88-0

345.36

C??H??N?

>98% (HPLC)

DMSO : 25 mg/mL (72.39 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble)

CN1N=CC(C2=CN=C3C(N([C@H](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1

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(-20℃)

With Ice Pack

≥ 2 years