Sangivamycin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sangivamycin 是一种有效的蛋白激酶 C (PKC，Ki = 10 μM) 抑制剂。 Sangivamycin 对多种人类癌症具有抗增殖活性。

Sangivamycin is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.(In Vitro):Sangivamycin (0.3 μM; 0-72 hours) exhibits almost maximal cytocidal for MCF7/ADR or cytostatic for MCF7/WT effects. Sangivamycin activates caspases in MCF7/ADR cells. Upon exposure of MCF7/ADR cells to Sangivamycin (0.3 μM), a vast amount of cleavage of lamin A to a 28-kDa fragment is detected within 48 hours. Sangivamycin has differential antitumor effects in drug-sensitive MCF7/wild type (WT) cells, causing growth arrest, and in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, causing massive apoptotic cell death.

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NSC 65346 | BA-90912

Cell Cycle/DNA Damage

Nucleoside Antimetabolite/Analog

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18417-89-5

309.28

C12H15N5O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (323.33 mM)

NC(c1cn([C@@H]([C@@H]2O)O[C@H](CO)[C@H]2O)c2ncnc(N)c12)=O

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(-20℃)

With Ice Pack

≥ 2 years