Salvigenin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Salvigenin 是一种有效的 hMAO-A 抑制剂，具有神经保护、抗肿瘤和免疫调节作用。

Salvigenin is a potent hMAO-A inhibitor has neuroprotective antitumor and immunomodulatory effects.

Salvigenin (0-100 μM, 3 h) protects SH-SY5Y cells against H2O2-induced cell death.Salvigenin (0-100 μM, 2 h) significantly reduces ROS generation, increases the glutathione level, declines the extent of cell apoptosis and increases autophagy in H2O2-exposed SH-SY5Y cells. Cell Viability Assay Cell Line:SY5Y cells exposed to H2O2 (300 μM)Concentration:10, 25, 50, and 100 μM Incubation Time:3 h Result:Protected SH-SY5Y cells (best in 25 and 50μM) against H2O2-induced cell death.Apoptosis Analysis Cell Line:SY5Y cells exposed to H2O2 (300 μM)Concentration:10, 25, 50, and 100 μM Incubation Time:2 h Result:Significantly declined the extent of cell apoptosis induced by H2O2.Western Blot Analysis Cell Line:SY5Y cells exposed to H2O2 (300 μM)Concentration:10, 25, 50, and 100 μM Incubation Time:2 h Result:Reduced cleaved caspase-3 and Bax/Bcl-2 ratio. Reduced caspase-12 and calpain levels. Reduced the level of Atg7, Atg12, and LC3-II/ LC3-I.

Salvigenin (0-9.68 μg/mouse/day; i.p.; 4 or 12 days) shows antitumor and immunomodulatory effects on tumor bearing mice. Animal Model:MCF-7 cell bearing inbred female Balb/c mice, aged from six to eight weeks Dosage:3.65, 5.85 and 9.68 μg/mouse/day for four days or 12 days Administration:Intraperitoneal injectionResult:Showed a significant increase in DTH response in a dose-dependent manner. Significantly decreased the rate of tumor growth, increased lymphocyte proliferation index, increased the level of IFN-γ and decreased IL-4 production. Exhibited a significant decrease of the splenic CD4+CD25+Foxp3+ T lymphocytes.

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Metabolic Enzyme/Protease

MAO

hMAO-A

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19103-54-9

328.32

C18H16O6

>98% (HPLC)

In Vitro:?DMSO : 20 mg/mL (60.92 mM)

COc1ccc(-c2cc(=O)c3c(O)c(OC)c(OC)cc3o2)cc1

5-hydroxy-67-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

(-20℃)

With Ice Pack

≥ 2 years