Sabeluzole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sabeluzole (R 58735) 是一种苯并噻唑衍生物，具有抗缺血、抗癫痫和增强认知的特性。Sabeluzole 通过阻止 tau 表达保护大鼠海马神经元免受 NMDA 和谷氨酸诱导的神经毒性。Sabeluzole 增强大鼠的记忆力，并防止 Chlordiazepoxide 的遗忘效应。Sabeluzole 可用于阿尔茨海默病研究。

Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease.

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Animal Model:Adult albino male rats (270-330 g) induced by Chlordiazepoxide Dosage:5 mg/kg, 25 mg/kg Administration:SC; 0.5 ml/kg; twice dose with 72 h interval; 1 h before 20 mg/kg Chlordiazepoxide Result:Showed the positive effects on several learning and memory tasks in rats.Did not influence locomotor and rearing activity of animals during the acquisition session.

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Others

Other Targets

Microtubule Associated

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104383-17-7

415.52

C22H26FN3O2S

>98% (HPLC)

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FC1=CC=C(OCC(O)CN2CCC(N(C3=NC=4C=CC=CC4S3)C)CC2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years