SU6656

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SU 6656 是 Src 家族激酶的选择性抑制剂，对 Src、Yes、Lyn 和 Fyn 的 IC50 分别为 280 nM、20 nM、130 nM 和 170 nM。

SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase. SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo.

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Animal Model:Swiss albino male mice Dosage:2, 4 mg/kg Administration:Intraperitoneal injection; once Result:Significantly decreased IPoCo mediated increase in fall down time.

SU6656 | SU 6656 | SU-6656

MAPK/ERK Signaling

Raf

Fyn| Lyn| Src| Yes

Cancer

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330161-87-0

371.45

C19H21N3O3S

>98% (HPLC)

DMSO : 18.5 mg/mL. 49.80 mM;

CN(C)S(=O)(=O)c1cc2c(cc1)NC(=O)/C/2=C\c1cc2c([nH]1)CCCC2

(Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide

(-20℃)

With Ice Pack

≥ 2 years