SJ6986

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SJ6986是一种用于研究GSPT1/2体外和体内作用的化学探针。 SJ6986 支持使用多样化的 CRBN 结合物库来靶向不可成药的癌蛋白。

SJ6986 is a chemical probe for studying the role of GSPT1/2 in vitro and in vivo. SJ6986 supports the utility of a diverse library of CRBN binders in the pursuit of targeting undruggable oncoproteins.

SJ6986 exhibits EC50 values of 1.5 nM, 0.4 nM, 726 nM, 336 nM and 3583 nM in MV4-11, MHH-CALL-4, MB002, MB004 and HD-MB03 cell lines, respectively. Cell Proliferation Assay Cell Line:MV4-11 cells.Concentration:0-100 μM.Incubation Time:3 days.Result:Exhibited EC50 of 1.5 nM.Western Blot Analysis Cell Line:MV4-11 cells.Concentration:0-10 μM.Incubation Time:4 and 24 h.Result:Dose- and time-dependently decreased the protein levels of GSPT1.

SJ6986 exhibits t1/2 of 3.44 h by iv injection of 3 mg/kg and tmax of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice.

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Others

Other Targets

ABCG2

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2765625-93-0

497.4

C20H14F3N3O7S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (201.05 mM)

O=C(N1)CCC(N2C(C(C=C(NS(C3=C(OC(F)(F)F)C=CC=C3)(=O)=O)C=C4)=C4C2=O)=O)C1=O

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(-20℃)

With Ice Pack

≥ 2 years