
SGC-707
CAS No. 1687736-54-4
SGC-707 ( SGC 707 | SGC707 )
产品货号. M12575 CAS No. 1687736-54-4
SGC-707 是一种有效的、选择性的、具有细胞活性的 PRMT3 变构抑制剂 (IC50=31 nM;Kd=53 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥478 | 有现货 |
![]() ![]() |
25MG | ¥794 | 有现货 |
![]() ![]() |
50MG | ¥1580 | 有现货 |
![]() ![]() |
100MG | ¥2795 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称SGC-707
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述SGC-707 是一种有效的、选择性的、具有细胞活性的 PRMT3 变构抑制剂 (IC50=31 nM;Kd=53 nM)。
-
产品描述SGC-707 is a potent, selective and cell-active allosteric inhibitor of PRMT3 (IC50=31 nM; Kd=53 nM); shows outstanding selectivity against 31 other methyltransferases and more than 250 non-epigenetic targets; active in cells, also bioavailable and suitable for animal studies.
-
体外实验Cell Viability Assay Cell Line:HEK293 and A549 cells Concentration:0-10 μM Incubation Time:6 hours Result:Stabilized PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.
-
体内实验Animal Model:Western-type diet-fed LDL (lipoprotein) receptor knockout mice Dosage:10 mg/kg Administration:Intraperitoneal injection; 10 mg/kg; 3 times per week; 3 weeks Result:Exhibited 50% lower liver triglyceride stores as well as 32% lower plasma triglyceride levels.
-
同义词SGC 707 | SGC707
-
通路Chromatin/Epigenetic
-
靶点HMTase
-
受体PRMT3
-
研究领域Other Indications
-
适应症——
化学信息
-
CAS Number1687736-54-4
-
分子量298.3397
-
分子式C16H18N4O2
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESO=C(NCC(N1CCCC1)=O)NC2=CC3=C(C=NC=C3)C=C2
-
化学全称Urea, N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Kaniskan HU, et al. Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70.