021-51111890
购物车（）
sales@molnova.cn
SCP1-IN-1
CAS No. 2764615-55-4
SCP1-IN-1 ( —— )
产品货号. M35319 CAS No. 2764615-55-4
SCP1-IN-1 (compoundSH T-62) 是一种针对 SCP1 的强效选择性共价抑制剂。SCP1-IN-1 促进 REST 降解并降低转录活性。高水平的 REST 蛋白驱动一些胶质母细胞瘤细胞的肿瘤生长。SCP1-IN-1 具有研究由 REST 转录活动驱动生长的胶质母细胞瘤的潜力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥581 | 有现货 |
|
| 5MG | ￥856 | 有现货 |
|
| 10MG | ￥1389 | 有现货 |
|
| 25MG | ￥2565 | 有现货 |
|
| 50MG | ￥3879 | 有现货 |
|
| 100MG | ￥5699 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称SCP1-IN-1
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述SCP1-IN-1 (compoundSH T-62) 是一种针对 SCP1 的强效选择性共价抑制剂。SCP1-IN-1 促进 REST 降解并降低转录活性。高水平的 REST 蛋白驱动一些胶质母细胞瘤细胞的肿瘤生长。SCP1-IN-1 具有研究由 REST 转录活动驱动生长的胶质母细胞瘤的潜力。
-
产品描述SCP1-IN-1 (compoundSH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-1 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity.
-
体外实验——
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Others
-
研究领域——
-
适应症——
化学信息
-
CAS Number2764615-55-4
-
分子量520.5
-
分子式C20H19F3N2O7S2
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (192.12 mM; 超声助溶 )
-
SMILESFC(F)(F)Oc1ccc(cc1)S(=O)(=O)NCCOCCNC(=O)C1=Cc2ccccc2S1(=O)=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519.?
产品手册
关联产品
-
cGMP Dependent Kinas...
Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by PKG. Inhibits phosphorylation of intact histones by PKA.
-
kaempferide
Kaempferide trigluside 通过一种不由配体结合依赖性雌激素受体激活介导的机制抑制天然和雌激素受体β过度表达的结肠癌细胞的增殖。
-
Maculosidin
Maculosidine affect the PS I electron acceptors on leaf discs, it can inhibit ATP synthesis, basal, phosphorylating and uncoupled electron transport acting as Hill reaction inhibitors on spinach chloroplasts.
