SBHA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SBHA（辛二羟肟酸）是一种组蛋白脱乙酰酶 (HDAC) 抑制剂。 HDAC 是转录调节、细胞周期调节和发育所必需的。

SBHA (suberohydroxamic acid) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones.

Suberoyl bis-hydroxamic acid (10, 20 or 50 μM; 24 hours) combination with TRAIL improves apoptosis extent, and when TRAIL is combined with 20 μM SBHA (itself causing only 10–15% apoptosis), resulting in 45–50% cell death.Suberoyl bis-hydroxamic acid (20-50 μM; 10-20 hours) alone has little effect on the expression of the proteins Bcl-xL, Mcl-1, and has albeit mildeffect on Bax. When it combines with TRAIL,which increases the ratio of relative protein expression of Bcl-xL and Bax in early periods, while the change in the ratio of Mcl-1 and Bax increases later in MM-BI and Ist-Mes2 cells.Suberoyl bis-hydroxamic acid (30 μM; 6 hours) causes accumulation of acetylated histone H4 in MEL cells. Apoptosis Analysis Cell Line:MM-BI and Ist-Mes2 cells Concentration:10 μM, 20 μM or 50 μM Incubation Time:24 hours Result:Showed a cooperative effect in cell apoptosis.

Suberoyl bis-hydroxamic acid (intraperitoneal injection; 200 mg/kg; every 2 days; 12 days) reveals a marked increase in the active form of Notch1(NICD) with a concomitant decrease in ASCL1. It reduces the MTC tumor growth. Animal Model:Nude mice injected with human MTC cells Dosage:200 mg/kg Administration:Intraperitoneal injection; every 2 days; 12 days Result:Resulted in an average 55% inhibition of tumor growth in SBHA treatment group.

Suberohydroxamic acid | Suberoyl bis-hydroxamic acid

Cell Cycle/DNA Damage

HDAC

HDAC1| HDAC3

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38937-66-5

204.22

C8H16N2O4

>98% (HPLC)

DMSO : 49 mg/mL (239.93 mM; Need ultrasonic); H2O : 8.16 mg/mL (40 mM; Need ultrasonic)

ONC(CCCCCCC(NO)=O)=O

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(-20℃)

With Ice Pack

≥ 2 years