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SB228357
CAS No. 181629-93-6
SB228357 ( —— )
产品货号. M33493 CAS No. 181629-93-6
SB228357 是一种选择性的，有效的具有口服活性的 5-HT2C/2B 受体拮抗剂，其对 5-HT2A，5-HT2B 和 5-HT2C 的 pKi 值分别为 6.9、8.0 和 9.0。SB228357 具有抗抑郁/抗焦虑作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥879 | 有现货 |
|
| 5MG | ￥1437 | 有现货 |
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| 10MG | ￥2398 | 有现货 |
|
| 25MG | ￥3840 | 有现货 |
|
| 50MG | ￥5114 | 有现货 |
|
| 100MG | ￥6839 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SB228357
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SB228357 是一种选择性的，有效的具有口服活性的 5-HT2C/2B 受体拮抗剂，其对 5-HT2A，5-HT2B 和 5-HT2C 的 pKi 值分别为 6.9、8.0 和 9.0。SB228357 具有抗抑郁/抗焦虑作用。
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产品描述SB228357 is a selective, potent and orall active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects.
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体外实验——
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体内实验SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy.Animal Model:Male Sprague Dawley rats (200-250?g) injected with Haloperidol Dosage:0 mg/kg, 0.32 mg/kg, 1 mg/kg, 3.2 mg/kg, 10 mg/kg Administration:Oral administration; for 90 minutes Result:Significantly reversed Haloperidol-induced catalepsy.
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同义词——
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通路GPCR/G Protein
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域——
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适应症——
化学信息
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CAS Number181629-93-6
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分子量431.38
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分子式C22H17F4N3O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 125 mg/mL (289.77 mM; 超声助溶 (<60°C)
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SMILESCOc1cc2CCN(C(=O)Nc3cc(F)cc(c3)-c3cccnc3)c2cc1C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bromidge SM, et al. Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/a?
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