SB-215505 ( —— )

产品货号. M34411 CAS No. 162100-15-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SB-215505
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SB-215505 是一种有效的，亚型选择性 5-HT2B 受体拮抗剂，对 5-HT2B，5-HT2A，5-HT2C 的 pKi 值分别为 8.3、6.77、7.66。SB-215505 可以增加大鼠的清醒和运动活动。
产品描述

SB-215505 is a potent and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively. SB-215505 increases wakefulness and motor activity in rats.
体外实验

SB-215505 is 30 fold selective for the 5-HT2B over the 5-HT2A receptor, and only marginally selective over the 5-HT2C receptor.
体内实验

SB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2.Animal Model:Male Sprague-Dawley rats weighing 230-260 g Dosage:0.1, 0.3 and 1.0 mg/kg Administration:IP; two doses (4 days between two doses) Result:Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2.
同义词

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通路

GPCR/G Protein
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

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适应症

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1. C Reavill, et al. Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4.?

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