S100P-IN-1 ( —— )

产品货号. M35653 CAS No. 690991-06-1

S100P-IN-1 (Compound 4) 是一种 S100P 抑制剂，其 IC50值为 22.7 nM。S100P-IN-1 对胰腺癌 (pancreatic) 细胞具有抗转移作用。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥1279	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

S100P-IN-1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

S100P-IN-1 (Compound 4) 是一种 S100P 抑制剂，其 IC50值为 22.7 nM。S100P-IN-1 对胰腺癌 (pancreatic) 细胞具有抗转移作用。
产品描述

S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC50 of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells.
体外实验

S100P-IN-1 (Compound 4) blocks S100P binding to RAGE in a dose dependent manner.S100P-IN-1 (10 μM, 24 h) shows S100P-specific inhibitory effect on cell invasion, without obvious cytotoxicity..Cell Invasion Assay Cell Line:Human pancreatic cancer cell lines PanC-1 (ATCC- CRL-1469), and BxPC-3 (ATCC-CRL-1687)Concentration:10 μM Incubation Time:48 h Result:Significantly inhibited invasion to the lower chamber in BxPC-3 cells, but didn’t inhibit invasion of PanC-1 (lack S100P expression) cells.Cell Viability Assay Cell Line:BxPC-3 and Panc-1 cells Concentration:10 μM Incubation Time:24 h Result:Showed no significant effect on cell metabolic activity and cytotoxicity in either cell line.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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化学信息

CAS Number

690991-06-1
分子量

440.4
分子式

C25H16N2O6
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (227.07 mM; 超声助溶 )
SMILES

O=C(O)C1=CC=CC(=C1)N2C(=O)C3C4C=5C=CC=CC5C(C=6C=CC=CC64)(N(=O)=O)C3C2=O
化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Ramatoulie Camara, et al. Discovery of novel small molecule inhibitors of S100P with in vitro anti-metastatic effects on pancreatic cancer cells. Eur J Med Chem. 2020 Oct 1;203:112621.?

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