021-51111890
购物车（0）
sales@molnova.cn
Roniciclib
CAS No. 1223498-69-8
Roniciclib ( BAY 10-00394 | BAY1000394 )
产品货号. M10856 CAS No. 1223498-69-8
一种新型强效口服活性泛 CDK 抑制剂，对 CDK1/2/4 的 IC50 分别为 7/9/11 nM，抑制转录 CDK9/7，IC50 为 5-25 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Roniciclib
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述一种新型强效口服活性泛 CDK 抑制剂，对 CDK1/2/4 的 IC50 分别为 7/9/11 nM，抑制转录 CDK9/7，IC50 为 5-25 nM。
-
产品描述A novel potent, orally active, pan-CDK inhibitor with IC50 of 7/9/11 nM for CDK1/2/4 respectively, inhibits transcriptional CDK9/7 with IC50 of 5-25 nM; inhibits 16 additional kinase in a panel of 214 non-CDK Ser/Thr and Tyr kinases; simultaneously inhibits cell-cycle progression and RNA polymerase II-mediated gene transcription, shows broad and uniform inhibitory activity on cell proliferation with IC50 of 8-33 nM, potently inhibits growth of various human tumor xenografts.Lung Cancer Phase 2 Discontinued.
-
体外实验——
-
体内实验——
-
同义词BAY 10-00394 | BAY1000394
-
通路Cell Cycle/DNA Damage
-
靶点CDK
-
受体CDK
-
研究领域Cancer
-
适应症Lung Cancer
化学信息
-
CAS Number1223498-69-8
-
分子量430.44
-
分子式C18H21F3N4O3S
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : ≥ 250 mg/mL (580.80 mM)
-
SMILESC[C@@H](O)[C@H](OC1=NC(NC2=CC=C(S(=N)(C3CC3)=O)C=C2)=NC=C1C(F)(F)F)C
-
化学全称(R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Siemeister G, et al. Mol Cancer Ther. 2012 Oct;11(10):2265-73.
2. Lücking U, et al. ChemMedChem. 2013 Jul;8(7):1067-85.
3. Ayaz P, et al. ACS Chem Biol. 2016 Jun 17;11(6):1710-9.
4. Bahleda R, et al. Br J Cancer. 2017 Jun 6;116(12):1505-1512.
产品手册
关联产品
-
(S)-Enitociclib
(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that induces complete regression of MYC+ lymphomas by inhibiting RNA polymerase II-mediated transcription of anti-apoptotic and pro-survival proteins.
-
AS-0141
AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM) with anti-tumor activity.
-
ICEC 0942
ICEC 0942 (CT7001) 是一种有效的、选择性的、口服活性的 CDK7 抑制剂，IC50 为 41 nM，选择性是 CDK2 的 15 倍 (IC50=578 nM)。
