Rimeporide ( EMD87580 | EMD-87580 )

产品货号. M12914 CAS No. 187870-78-6

Rimeporide (EMD87580) 是一种有效的选择性钠氢交换器 NHE1 抑制剂。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥478	有现货
5MG	￥786	有现货
10MG	￥1442	有现货
25MG	￥3216	有现货
50MG	￥4714	有现货
100MG	￥6715	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Rimeporide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Rimeporide (EMD87580) 是一种有效的选择性钠氢交换器 NHE1 抑制剂。
产品描述

Rimeporide (EMD87580) is a potent, selective sodium hydrogen exchanger NHE1 inhibitor, show promise as potential therapeutic agents for the treatment of heart failure.Heart Failure Discontinued(In Vitro):Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.
体外实验

Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.
体内实验

——
同义词

EMD87580 | EMD-87580
通路

Membrane Transporter/Ion Channel
靶点

Sodium Channel
受体

NHE-1
研究领域

——
适应症

——

化学信息

CAS Number

187870-78-6
分子量

333.377
分子式

C11H15N3O5S2
纯度

>98% (HPLC)
溶解度

DMSO: 15 mg/mL,50 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CC1=CC(=C(C=C1C(=O)NC(=N)N)S(=O)(=O)C)S(=O)(=O)C
化学全称

N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Cox CS Jr, et al. Chest. 2003 Jan;123(1):187-94. 2. Corvera JS, et al .Ann Thorac Surg. 2003 Nov;76(5):1614-22. 3. Chen L, et al. Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H381-7. 4. Javadov S, et al. J Mol Cell Cardiol. 2005 Jan;38(1):135-43.

计算器

浓度计算器

摩尔计算器

分子量计算器

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