RJW100

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RJW100 是一种有效的肝受体同源物 1 (LRH-1，NR5A2) 和类固醇生成因子-1 (SF-1，NR5A1) 激动剂，pEC50 分别为 6.6 和 7.5。RJW100 还可有效激活 miR-200c (miRNA-200c, microRNA-200c) 启动子。

RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.

RJW100 (compound 24-exo) treatment induces a significant dose-dependent increase in small/short heterodimer partner (SHP) transcripts beginning at 5 μM.RJW100 (compound 24-exo) clearly displaces the bound PIP2 phospholipid from SF-1 almost completely at 1 μM.Using hLRH-1 LBD alone that had not been complexed with any phospholipids, the result shows a clear dose-dependent shift in hLRH-1 LBD (ligand binding domain) native PAGE migration upon RJW100 (compound 24-exo; 0-100 μM) binding.RJW100 causes strong activation of the miR-200c promoter and exhibits strong ability to downregulate ZEB1 and ZEB2 proteins..RT-PCR Cell Line:HEK293 cells Concentration:1 μM, 5 μM, 10 μM Incubation Time:24 hours Result:Induced a significant dose-dependent increase in SHP transcripts beginning at 5 μM.

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Others

Other Targets

Others

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1276664-20-0

386.57

C28H34O

>98% (HPLC)

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C(=C)([C@]12C(=C(CCCCCC)C[C@]1([C@H](O)CC2)[H])C3=CC=CC=C3)C4=CC=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years