Prezalumab

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Prezalumab (AMG 557) 是一种靶向 ICOSL 和 BAFF 的人源 IgG2 单克隆抗体。Prezalumab 对系统性红斑狼疮关节炎有研究作用。Prezalumab 可用于干燥综合征皮肤红斑狼疮、银屑病和系统性红斑狼疮 (SLE) 的研究。

Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE).

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Prezalumab shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models.Prezalumab reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition.Pharmacokinetic Properties of Prezalumab in Cynomolgus Monkeys.Cynomolgus MonkeysIV10 mg/kg,Cynomolgus MonkeysSC 10 mg/kg.

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Others

Other Targets

Others

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1523164-68-2

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years