Phloretin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Phloretin 是一种众所周知的真核尿素转运蛋白抑制剂，可阻断 VacA 介导的尿素和离子转运。

Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. It promotes potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells.

Apoptosis Analysis Cell Line:BEL-7402 cell Concentration:40-160 μM Incubation Time:24 hours Result:Induced cell apoptosis and activated caspase 3, 6 and 9.Western Blot AnalysisCell Line:3T3-L1 adipocytes Concentration:0 μM, 3 μM, 10 μM, 30 μM, 100 μM Incubation Time:24 hours Result:Inhibited PPAR-γ, C/EBPα and C/EBPβ expression. Western Blot Analysis Cell Line:3T3-L1 adipocytes Concentration:0 μM, 3 μM, 10 μM, 30 μM, 100 μM Incubation Time:24 hours Result:Upregulated the expression of p-ACC-1, p-AMPK, p-AMPKα and β .

Animal Model:Collagen-Induced Arthritis (CIA) MiceDosage:50 or 100?mg/kg Administration:Oral adminstration Result:Showed mitigation of clinical symptoms of RA in addition to reduced inflammation of hind-limbs compared to the control group.

NSC 407292 | RJC 02792

Others

Other Targets

SGLT1| SGLT2

Metabolic Disease

——

60-82-2

274.28

C15H14O5

>98% (HPLC)

DMSO : 50 mg/mL 182.30 mM; H2O : < 0.1 mg/mL

c1(c(c(cc(c1)O)O)C(=O)CCc1ccc(cc1)O)O

——

(-20℃)

With Ice Pack

≥ 2 years