
Pentachloropseudilin
CAS No. 69640-38-6
Pentachloropseudilin ( —— )
产品货号. M34015 CAS No. 69640-38-6
Pentachloropseudilin (Antibiotic A 15104 Y; PClP) 是一种可逆的、变构有效的肌球蛋白 (Myo1s) 抑制剂,对 Myo1s 的 IC50 范围为 1 至 5 μM,对于 2 类和 5 类肌球蛋白,IC50 范围 > 90 μM。Pentachloropseudilin 是转化生长因子-β (TGF-β) 刺激的信号传导的有效抑制剂,对 TGF-β 的 IC50 值为 0.1-0.2 μM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
25MG | ¥11886 | 有现货 |
![]() ![]() |
50MG | ¥15484 | 有现货 |
![]() ![]() |
100MG | ¥19125 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Pentachloropseudilin
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Pentachloropseudilin (Antibiotic A 15104 Y; PClP) 是一种可逆的、变构有效的肌球蛋白 (Myo1s) 抑制剂,对 Myo1s 的 IC50 范围为 1 至 5 μM,对于 2 类和 5 类肌球蛋白,IC50 范围 > 90 μM。Pentachloropseudilin 是转化生长因子-β (TGF-β) 刺激的信号传导的有效抑制剂,对 TGF-β 的 IC50 值为 0.1-0.2 μM。
-
产品描述Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β.
-
体外实验Pentachloropseudilin (PClP) inhibits TGF-β-stimulated Smad2/3 phosphorylation and plasminogen activator inhibitor-1 (PAI-1) promoter activation with an IC50 of 0.1 μM in target cells (A549, HepG2, and Mv1Lu cells).Pentachloropseudilin attenuates TGF-β-stimulated expression of vimentin, N-cadherin, and fibronectin and, thus, blocks TGF-β-induced epithelial to mesenchymal transition (EMT) in these cells.Pentachloropseudilin (0.05 to 1 μΜ; 0-6 hours) pretreatment inhibits TGF-β-mediated (50 or 100 pM) increases in p-Smad2/3 expression to 47% (Mv1Lu) and 79% (A549), respectively. Pentachloropseudilin (0.2 μM) suppresses TGF-β-stimulated cellular responses by attenuating cell-surface expression of the type II TGF-β receptor through accelerating caveolae-mediated internalization followed by primarily lysosome-dependent degradation of the receptor, as demonstrated by sucrose density gradient analysis and immune fluorescence staining.Pentachloropseudilin (200 μM; 24 hours) exhibits and altered cell viability in HUVECs.
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体TGF-beta/Smad | Antibiotic | Myosin
-
研究领域——
-
适应症——
化学信息
-
CAS Number69640-38-6
-
分子量331.41
-
分子式C10H4Cl5NO
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (301.74 mM; 超声助溶 )
-
SMILESOc1c(Cl)cc(Cl)cc1-c1[nH]c(Cl)c(Cl)c1Cl
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Chinthalapudi K, et al. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011;286(34):29700-29708.?
产品手册




关联产品
-
GR-73632
速激肽神经激肽1 (NK-1) 受体激动剂。 GR-73632 通过传递瘙痒信号的 NK1 受体直接作用于初级感觉神经元的外周末端
-
3,4,7,8-Tetramethoxy...
3',4',7,8-Tetramethoxyflavone has antioxidant activity.
-
Geranylacetone
香叶丙酮具有抑制锥虫的活性,可以通过抑制唾液酸酶和/或保护寄生虫引起的肝脾肿大来保护动物免受刚果锥虫引起的贫血。