Peimine ( 5α-Cevane-3β,6α,20-triol | Verticine | Dihydroisoimperialine )

产品货号. M18278 CAS No. 23496-41-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Peimine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Peimine 是一种抑制剂，通过阻断 MAPK 和 NF-κB 信号通路来抑制 LPS 诱导的炎症细胞因子的产生。
产品描述

Peimine, also known as Verticine, is a known MAPK inhibitor, as well as an inhibitor of p38, ERK and JNK phosphorylation, and NFκB activation. Peimine shows antitussive, expectorant and anti-inflammatory effects in vivo. Peimine inhibits the growth and motility of prostate cancer cells and induces apoptosis by disruption of intracellular calcium homeostasis through Ca2+ /CaMKII/JNK pathway.
体外实验

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体内实验

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同义词

5α-Cevane-3β,6α,20-triol | Verticine | Dihydroisoimperialine
通路

Others
靶点

Other Targets
受体

Others
研究领域

Inflammation/Immunology
适应症

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CAS Number

23496-41-5
分子量

431.66
分子式

C27H45NO3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 50 mg/mL (115.83 mM)
SMILES

CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(C6C5(CCC(C6)O)C)O)(C)O
化学全称

(3S,4aS,5S,6aS,6bS,8aS,9S,9aS,12S,15aR,15bR,16aR,16bS)-9,12,16b-trimethyltetracosahydrobenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinoline-3,5,9-triol