PTGR2-IN-22

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PTGR2-IN-22 是 PTGR2r 的有效抑制剂 (IC50 : 0.7 μM)。它增加 PTGR2 转染的 HEK293T 细胞中 15-keto-PGE2 依赖性 PPARγ 转录活性。

PTGR2-IN-22 is a potent inhibito of PTGR2r(IC50 : 0.7 μM). It increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells.

A screen of structural analogs of 20 identified PTGR2-IN-1, which shows substantially increased potency (>20-fold) in assays measuring either competition of 8-labeling or 15-keto-PGE2 reductase activity (IC50 = 0.6 μM) of recombinant PTGR2, as well as an inactive control compound 23. PTGR2-IN-1 (Compound 22) blocks FFF 8 labeling of endogenous PTGR2 in HEK293T cells with good potency (complete inhibition at 5 μM and ~80% inhibition at 500 nM) and excellent selectivity.

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Others

Other Targets

PTGR2

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349093-44-3

310.39

C19H22N2O2

>98% (HPLC)

DMSO:100 mg/mL (322.18 mM; Need ultrasonic)

COC1=CC=CC=C1N2CCN(C(CC3=CC=CC=C3)=O)CC2

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(-20℃)

With Ice Pack

≥ 2 years