PF9366

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PF-9366 是一种人蛋氨酸腺苷转移酶 2A (Mat2A) 抑制剂（IC50：420 nM；Kd：170 nM）。

PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).

PF-9366 is a Mat2A inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. PF-9366 displays no substantial off-target activity in GPCRs, neurotransporters, phosphodiesterases, and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC50 of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC50 of 255 nM, and also suppresses the proliferation of cells with an IC50 of 10 μM.

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PF 9366 | PF-9366

Others

Other Targets

Mat2A

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72882-78-1

350.84

C20H19ClN4

>98% (HPLC)

DMSO: 20 mg/mL (57 mM)

CN(C)CCc1nnc2cc(-c3ccccc3)c3cc(Cl)ccc3n12

2-(7-Chloro-5-phenyl-[124]triazolo[43-a]quinolin-1-yl)-NN-dimethylethan-1-amine

(-20℃)

With Ice Pack

≥ 2 years