PF-04957325

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PF-04957325是一种高效，选择性的 PDE8 抑制剂，抑制PDE8A和PDE8B的IC50值分别为0.7 nM和0.3 nM。

PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.

PF-04957325 is over two orders of magnitude less efficient than PICL in suppressing polyclonal Teff cell proliferation, and shows no effect on cytokine gene expression in these cells, despite its robust effect on T cell adhesion. PF-04957325 is a selective PDE8 inhibitor and inhibits breast cancer cell migration. PF-04957325 greatly potentiates steroidogenesis in WT adrenal cells. PF-04957325 shows a reported IC50 of 0.7 nM against PDE8A, 0.2 nM against PDE8B, and > 1.5 μM against all other PDE isoforms. PF-04957325 treatment of WT Leydig cells or MA10 cells increases steroid production but has no effect in PDE8A (-/-)/B(-/-) double-knockout cells, confirming the selectivity of the drug. Moreover, under basal conditions, cotreatment with PF-04957325 plus rolipram, a PDE4-selective inhibitor, synergistically potentiates steroid production.

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Angiogenesis

PDE

PDE

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1305115-80-3

400.38

C14H15F3N8OS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 100 mg/mL (249.76 mM )

Nc1nc(nc2n(C[C@H]3CN(Cc4nccs4)CCO3)nnc12)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years