PBT-1033 ( PB 1033 | PBT-2 | PBT1033 | PBT2 | PBT 1033 | PBT 2 )

产品货号. M24759 CAS No. 747408-78-2

PBT-1033(PBT-2) 是一种潜在的神经保护剂，用于治疗阿尔茨海默病和亨廷顿舞蹈病。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥551	有现货
5MG	￥810	有现货
10MG	￥1199	有现货
25MG	￥2130	有现货
50MG	￥3167	有现货
100MG	￥4739	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

PBT-1033
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PBT-1033(PBT-2) 是一种潜在的神经保护剂，用于治疗阿尔茨海默病和亨廷顿舞蹈病。
产品描述

PBT-1033(PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
体外实验

PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5?μM.PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity.PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons.PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells.PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates. Western Blot Analysis Cell Line:SH-SY5Y cells Concentration:0-10 μM Incubation Time:1 h Result:Increased in cellular levels of GSK3α/β phosphorylated at the inhibitory serine 21/9 residue (ser21/9 on GSK3α/β).
体内实验

PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease. Animal Model:Female Tg2576 miceDosage:30 mg/kg/d Administration:Oral administration, 11 days Result:Increased hippocampal apical spine density, basal spine density.
同义词

PB 1033 | PBT-2 | PBT1033 | PBT2 | PBT 1033 | PBT 2
通路

Others
靶点

Other Targets
受体

others
研究领域

——
适应症

——

化学信息

CAS Number

747408-78-2
分子量

271.14
分子式

C12H12Cl2N2O
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (368.81 mM)
SMILES

CN(C)Cc1ccc(c(Cl)cc(Cl)c2O)c2n1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Huntington Study Group Reach2HD Investigators.. Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Jan;14(1):39-47. doi: 10.1016/S1474-4422(14)70262-5. PubMed PMID: 25467848.

计算器

浓度计算器

摩尔计算器

分子量计算器

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