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PACOCF3
CAS No. 141022-99-3
PACOCF3 ( —— )
产品货号. M33771 CAS No. 141022-99-3
PACOCF3 (Palmityltrifluoromethylketone) 是一种选择性磷脂酶 A2 (phospholipase A2) 抑制剂，IC50 为 3.8 μM。PACOCF3 改变肾小管细胞中的 Ca2+ 信号传导。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥315 | 有现货 |
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| 10MG | ￥444 | 有现货 |
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| 25MG | ￥766 | 有现货 |
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| 50MG | ￥1314 | 有现货 |
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| 100MG | ￥2081 | 有现货 |
|
| 200MG | ￥3029 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PACOCF3
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PACOCF3 (Palmityltrifluoromethylketone) 是一种选择性磷脂酶 A2 (phospholipase A2) 抑制剂，IC50 为 3.8 μM。PACOCF3 改变肾小管细胞中的 Ca2+ 信号传导。
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产品描述PACOCF3 (Palmityltrifluoromet?hylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.
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体外实验At a concentration of 20 μM, PACOCF3 does not change basal cytosolic free calcium concentrations ([Ca2+]i), but at concentrations of 50-250 μM PACOCF3 induced an increase in [Ca2+]i by activating extracellular Ca2+ entry which is partly suppressed by 50 μM La3+. The effect of PACOCF3 is abolished by removal of extracellular Ca2+. PACOCF3 (10 μM) enhances both the peak value and the area under the curve of the [Ca2+]i increase induced by 10 μM ATP and 1 μM bradykinin by potentiating extracellular Ca2+ influx without affecting internal Ca2+ release.
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体内实验——
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Phospholipase
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受体Phospholipase
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研究领域——
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适应症——
化学信息
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CAS Number141022-99-3
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分子量308.42
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分子式C17H31F3O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 33.33 mg/mL (108.07 mM; 超声助溶 )
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SMILESCCCCCCCCCCCCCCCC(=O)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. E J Ackermann, et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 6;270(1):445-50. ?
