Olorofim ( —— )

产品货号. M34247 CAS No. 1928707-56-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

Olorofim
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Olorofim（F-901318）is a novel selective antifungal compound targeting pyrimidine biosynthesis in mycobacteria, with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM), but little inhibitory effect on human DHODH (>100 uM).Olorofim has good efficacy against a variety of pathogenic filamentous and dimorphic fungi, such as Penicillium spp, P. dermatitidis spp and Fusarium spp.
产品描述

Olorofim（F-901318）is a novel selective antifungal compound targeting pyrimidine biosynthesis in mycobacteria, with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM), but little inhibitory effect on human DHODH (>100 uM).Olorofim has good efficacy against a variety of pathogenic filamentous and dimorphic fungi, such as Penicillium spp, P. dermatitidis spp and Fusarium spp.
体外实验

——
体内实验

——
同义词

——
通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

Dehydrogenase | Antifungal
研究领域

——
适应症

——

CAS Number

1928707-56-5
分子量

498.55
分子式

C28H27FN6O2
纯度

>98% (HPLC)
溶解度

——
SMILES

C(C(NC1=CC=C(C=C1)N2CCN(CC2)C=3N=CC(F)=CN3)=O)(=O)C4=C(C=C(C)N4C)C5=CC=CC=C5
化学全称

——

计算器

产品手册

关联产品

Glomeratose A

Glomeratose A 是一种乳酸脱氢酶抑制剂。
Propachlor

丙草胺是 ALDH1A1 的抑制剂，是一种用于芽前的乙酰胺除草剂。
Tenuifoliside C

Tenuifoliaide C 是从远志中分离出来的，是一种目标乳酸脱氢酶抑制剂。它显着抑制 CYP2E1 催化的氯唑沙宗 6-羟基化。