
Oleoylcarnitine
CAS No. 38677-66-6
Oleoylcarnitine ( —— )
产品货号. M33043 CAS No. 38677-66-6
Oleoylcarnitine 是一种通过抑制脂肪酸 β-氧化而积累的代谢物,可通过 STAT3 的激活而增强肝癌的发生。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥672 | 有现货 |
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5MG | ¥1090 | 有现货 |
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10MG | ¥1583 | 有现货 |
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25MG | ¥2628 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Oleoylcarnitine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Oleoylcarnitine 是一种通过抑制脂肪酸 β-氧化而积累的代谢物,可通过 STAT3 的激活而增强肝癌的发生。
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产品描述Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.
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体外实验Oleoylcarnitine (AC18:1) (5, 25, 50 μM; 24, 48 hours) concentration significantly increases in the Dih10 cells with stable CPT2 knock down.Oleoylcarnitine (5 μM, 24 hours) contributes directly to hepatocarcinogenesis by conferring stem cell properties to cancer cells through STAT3 activation.Cell Viability Assay Cell Line:Dih 10 cells, HCC cells Concentration:5, 25, 50 μM Incubation Time:24, 48 hours Result:Enhanced the self-renewal of HCC cells through STAT3 activation.
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体内实验Oleoylcarnitine (AC18:1) accumulates markedly in obesity-driven HCC tissues of mice.Animal Model:MUP-uPA and PIK3CA Tg mice.Dosage:Administration:High-fat diet (HFD) for miceResult:Accumulated in HCC tissues and in the serum of HFD-fed mice.
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同义词——
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通路Proteasome/Ubiquitin
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靶点Endogenous Metabolite
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受体Endogenous Metabolite
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研究领域——
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适应症——
化学信息
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CAS Number38677-66-6
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分子量425.64
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分子式C25H47NO4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (234.94 mM; 超声助溶 (<60°C)
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SMILESCCCCCCCC\C=C/CCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Fujiwara N, et al. CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity. Gut. 2018 Aug;67(8):1493-1504.?
产品手册




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