Oglufanide ( H-Glu-Trp-OH | L-Glutamyl-L-tryptophan )

产品货号. M20677 CAS No. 38101-59-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Oglufanide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Oglufanide 是一种天然存在的胸腺免疫调节剂，可抑制血管内皮生长因子 (VEGF)。
产品描述

Oglufanide is a naturally occurring thymic immunomodulatorand inhibits vascular endothelial growth factor (VEGF).
体外实验

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体内实验

Animal Model:C57BL/6 immune competent mice, Lewis lung carcinoma (LLC) xenograft; Balb/C athymic mice, M21 human melanoma xenograftDosage:1, 10, 50 and 100 mg/kg/day Administration:Subcutaneous injection, 10 days Result:Resulted in a dose-dependent inhibition of LLC tumor growth in syngeneic immune competent mice and showed a dose-dependent decrease in tumor volumes of xenografts in Balb/C athymic mice implanted with M21 human melanoma cells.
同义词

H-Glu-Trp-OH | L-Glutamyl-L-tryptophan
通路

Angiogenesis
靶点

VEGFR
受体

VEGFR
研究领域

Infection
适应症

Colorectal Cancer; Hepatitis C; Influenza virus infections; Kaposi's sarcoma; Ovarian Cancer

CAS Number

38101-59-6
分子量

333.34
分子式

C16H19N3O5
纯度

>98% (HPLC)
溶解度

DMSO:15.5 mg/mL (46.50 mM)
SMILES

N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
化学全称

(S)-4-amino-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid