ONO-AE3-208

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ONO-AE3-208 是一种 EP4 拮抗剂。它抑制前列腺癌的细胞迁移、侵袭和转移。

ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.

ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208.

ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls.

AE 3-208

GPCR/G Protein

Prostaglandin Receptor

EP4

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402473-54-5

404.43

C24H21FN2O3

>98% (HPLC)

DMSO:40 mg/mL (98.9 mM);Water: Insoluble

CC(C(Nc1c(CCCC(O)=O)ccc(C#N)c1)=O)c(c1ccccc11)ccc1F

——

(-20℃)

With Ice Pack

≥ 2 years