Nestorone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nestoron (ST-1435) 是一种 19-norprogesterone 衍生物，对 progesterone receptors 具有高亲和力和选择性，是一种高度选择性和有效的孕激素，可用作激素避孕药。

Nestoron2 (ST1435, Elcometrine) is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive, a high-affinity agonist of the progesterone receptor.Other Indication Discontinued(In Vivo):Nestoron (400 μCi 3H Nestoron/kg BW; subcutaneous injection; female Sprague-Dawley rats) treatment results in the Cmax in the blood and plasma are 58.1 and 95.5 ng equiv. 3H Nestoron/g, with t1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose is excreted via feces and urine, respectively.

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Nestoron (400 μCi 3H Nestoron/kg BW; subcutaneous injection; female Sprague-Dawley rats) treatment results in the Cmax in the blood and plasma are 58.1 and 95.5 ng equiv. 3H Nestoron/g, with t1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose is excreted via feces and urine, respectively. Animal Model:27 adult, female, Sprague-Dawley rats (200-225 g; age: 8 weeks)Dosage:400 μCi 3H Nestorone/kg BWAdministration:Subcutaneous injection (Pharmacokinetic study)Result:The mean peak concentrations of radioactivity (Cmax) in the blood and plasma were 58.1 and 95.5 ng equiv./g, with t1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose was excreted via feces and urine, respectively.

Elcometrine | Nestorone | ST-1435 | ST1435

GPCR/G Protein

Prostaglandin Receptor

PR

Other Indications

Other Disease

7759-35-5

370.4819

C23H30O4

>98% (HPLC)

10 mM in DMSO

CC([C@@]1(OC(C)=O)C(C[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4([H])[C@@]3([H])CC[C@]12C)=O)=C)=O

19-Norpregn-4-ene-3,20-dione, 17-(acetyloxy)-16-methylene-

(-20℃)

With Ice Pack

≥ 2 years