NMS-859

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NMS-859 是一种有效的含缬氨肽蛋白 (VCP)/p97 的共价抑制剂，在细胞中存在 60 μM 和 1 mM ATP 的情况下，对野生型 VCP 的 IC50 值分别为 0.37 μM 和 0.36 μM。

NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.(In Vitro):NMS-859 suppresses the cell proliferation with IC50s of 3.0 μM and 3.5 μM in HeLa and HCT116 cell lines, respectively. NMS-859 shows weak inhibitory activity against VCPC522T.

NMS-859 is a potent VCP inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. NMS-859 shows very weak inhibitory activity against VCPC522T. NMS-859 also suppresses the proliferation of cells, with IC50s of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively.

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ZINC169324353

Others

Other Targets

ADC Cytotoxin| Microtubule/Tubulin

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1449236-96-7

349.79

C15H12ClN3O3S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (142.94 mM)

ClCC(=O)Nc1cccc(NC2=NS(=O)(=O)c3ccccc23)c1

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(-20℃)

With Ice Pack

≥ 2 years