NBI-98782

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NBI-98782 是一种囊泡单胺转运蛋白 (VMAT2) 抑制剂（Ki：0.97 nM）

NBI-98782 is an inhibtior of vesicular monoamine transporter (VMAT2) ?(Ki: 0.97 nM).

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Animal Model:Male C57BL/6J miceDosage:10 mg/kg Administration:p.o., daily for 7 daysResult:Decreased the efflux of DA, 5-HT and NE in mPFC, dSTR, HIP and NAC.Increased the efflux of DOPAC, HVA, and 5-HIAA in mPFC, dSTR, HIP and NAC.Decreased in cortical DA and DOPAC as well as striatal DA, 5-HT and NE efflux combinated with haloperidol (HY-14538, 0.5 mg/kg, i.p.).Decreased cortical Glu and striatal ACh, DA and GABA efflux combinated with Clozapine (HY-14539, 10 mg/kg, i.p.).Reduced PCP-induced increase in LMA between various time points.Suppressed clozapine-, olanzapine- and risperidone-induced DA efflux in both mPFC and dSTR, and ACh efflux in mPFC.

(+)-DTBZ | (+)-α-Dihydrotetrabenazine | (+)-α-DHTBZ

Membrane Transporter/Ion Channel

Monoamine Transporter

VMAT2

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85081-18-1

319.44

C19H29NO3

>98% (HPLC)

DMSO:33.33 mg/mL (104.34 mM)

COc1cc2c(cc1OC)C1CC(O)C(CC(C)C)CN1CC2

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(-20℃)

With Ice Pack

≥ 2 years