NAP

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Davunetide 是一种八个氨基酸多肽，来源于活性依赖性神经保护蛋白 (ADNP)，一种存在于哺乳动物中枢神经系统中的神经营养因子。Davunetide 具有神经保护、神经营养和认知保护特性。Davunetide 是一种微管稳定肽 (microtubule-stabilizing)，在体外与神经元特异性βIII微管蛋白相互作用并稳定其活性。Davunetide 可透过血脑屏障，无毒。Davunetide 抑制Aβ聚集和Aβ诱导的神经毒性。

Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic.Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity.

Davunetide (2 μg/kg；鼻内；每天，每周 5 天，持续 16 周) 在糖尿病大鼠模型中显示出对中枢神经系统并发症的保护作用。Animal Model:Male Sprague-Dawley rats (Induced by an i.p. streptozotocin (STZ) injection) Dosage:2 μg/kg Administration:Intranasally beginning on the day following the STZ injection and were given daily, 5 days a week, for 16 weeks Result:Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. Davunetide treatment significantly improved both measurements.

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Others

Other Targets

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211439-12-2

824.94

C36H60N10O12

>98% (HPLC)

DMSO : 125 mg/mL (151.53 mM; ultraphonic; ) H2O : 100 mg/mL (121.22 mM; ultraphonic)

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(-20℃)

With Ice Pack

≥ 2 years