Acid-sensing ion channel 3 (ASIC3) channel blocker (IC50 values are 63 and 175 nM for homomeric rat and human ASIC3 channels). Also inhibits NaV1.8 and NaV1.2 channels (IC50 values are 55 and 114 nM respectively). Demonstrates analgesic properties against acid-induced and inflammatory pain.

CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) 是一种有效的选择性 Nav1.7 钠通道阻滞剂。

Levobupivacaine HCl 是布比卡因的纯 S(-)-对映体，是一种可逆性神经元钠通道抑制剂，用作长效局部麻醉剂。