TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells.

Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.

6,7,4'-三羟基异黄酮是一种新型 PKCα 抑制剂，可抑制太阳紫外线诱导的基质金属蛋白酶 1，具有抗氧化和抗癌活性。分子研究表明，6,7,4'-THIF 显着抑制乙酰胆碱酯酶东莨菪碱诱导的小鼠海马体和硫代巴比妥酸反应物质（TBARS）的活性。