
MeTC7
CAS No. 1817841-22-7
MeTC7 ( —— )
产品货号. M36330 CAS No. 1817841-22-7
MeTC7 是一种维生素 D 受体 (VDR) 拮抗剂。MeTC7 具有有效的 VDR 抑制活性,IC50 值为 2.9 μM。MeTC7 显示出良好的抗肿瘤作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥594 | 有现货 |
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5MG | ¥1122 | 有现货 |
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10MG | ¥2083 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称MeTC7
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述MeTC7 是一种维生素 D 受体 (VDR) 拮抗剂。MeTC7 具有有效的 VDR 抑制活性,IC50 值为 2.9 μM。MeTC7 显示出良好的抗肿瘤作用。
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产品描述MeTC7 is a Vitamin-D receptor (VDR) antagonist. MeTC7 has potent VDR inhibition activity with an IC50 value of 2.9 μM. MeTC7 shows good antitumor effects.
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体外实验MeTC7 (compound 5) shows potent VDR inhibition activity with an IC50 value of 2.9 μM.MeTC7 disrupts the VDR-Ligand-binding domain in Silico.MeTC7 (250 nM; 18 h) suppresses RXRα and Importin-4 expressions in the ovarian cancer cell-line.MeTC7 (250 nM; 18 h) inhibits the viability of ovarian cancer cells and induces PARP1 cleavage.Western Blot Analysis Cell Line:2008 cells Concentration:250 nM Incubation Time:18, 12 h Result: Reduced the expression of RXR-α, Importin-4 and increased cleaved PARP1 expression in 2008 cells.Cell Viability Assay Cell Line:SKOV-3, IGROV-1, CAOV-3, OVCAR-3, OVCAR-8, and 2008 ovarian cancer cell-lines Concentration:0, 0.25, 0.5, 0.75, 1.0, 1.25 μM Incubation Time:24 h Result:Reduced the viability of SKOV-3, IGROV-1, CAOV-3, OVCAR-3, OVCAR-8, and 2008 ovarian cancer cell-lines.
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体内实验MeTC7 (compound 5) (i.p.; 10 mg/kg) reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo.Animal Model:Mice Dosage:10 mg/kg Administration:IP Result:Reduced the growth of xenografts derived from ovarian cancer, medulloblastoma, and pancreatic cancer cells.Inhibited the growth of neuroblastoma cells and Xenografts.Reduced MYCN expression and blocked the growth of TH-MYCN transgene-driven spontaneous neuroblastoma.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Vitamin
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受体Vitamin
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研究领域——
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适应症——
化学信息
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CAS Number1817841-22-7
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分子量618.65
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分子式C32H48BrN3O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 16.67 mg/mL (26.95 mM; 超声助溶 (<60°C)
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SMILESO=C1N2C34[C@@]([C@]5(C)C(N2C(=O)N1C)(C=C3)C[C@@H](OC(CBr)=O)CC5)(CC[C@@]6(C)[C@]4(CC[C@@]6([C@@H](CCCC(C)C)C)[H])[H])[H]
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Negar Khazan, et al. Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo. J Med Chem?
产品手册




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