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Marbostat-100
CAS No. 1876450-69-9
Marbostat-100 ( Marbostat 100 )
产品货号. M12908 CAS No. 1876450-69-9
Marbostat-100 是一种有效的选择性 HDAC6 抑制剂，Ki 为 0.7 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Marbostat-100
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Marbostat-100 是一种有效的选择性 HDAC6 抑制剂，Ki 为 0.7 nM。
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产品描述Marbostat-100 is a potent, selective HDAC6 inhibitor with Ki of 0.7 nM, displays >200-fold selectivity over HDAC1-5, and HDAC7-10; Marbostat-100 is a more selective HDAC6i than previously established well-characterized compounds; Marbostat-100 is well tolerated by mice and demonstrates in vivo anti-inflammatory activity against collagen type II induced arthritis, represents a most selective known HDAC6i and the possibility for clinical evaluation of a HDAC isoform-specific drug.
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体外实验——
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体内实验——
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同义词Marbostat 100
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC
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研究领域——
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适应症——
化学信息
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CAS Number1876450-69-9
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分子量404.426
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分子式C22H20N4O4
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称N-Hydroxy-4-((4-methyl-3,5-dioxo-3,4,5,6-tetrahydro-2,6-methano[1,3]diazocino[5,6-b]indol-11(1H)-yl)methyl)benzamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sellmer A, et al. J Med Chem. 2018 Apr 6. doi: 10.1021/acs.jmedchem.7b01593.
