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MRT-83

CAS No. 1263131-92-5

MRT-83 ( —— )

产品货号. M26307 CAS No. 1263131-92-5

MRT-83 是一种有效的 Smo 拮抗剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥510 有现货
5MG ¥786 有现货
10MG ¥1256 有现货
25MG ¥2608 有现货
50MG ¥4496 有现货
100MG ¥6342 有现货
500MG ¥13365 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    MRT-83
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    MRT-83 是一种有效的 Smo 拮抗剂。
  • 产品描述
    MRT-83 is a potent Smo antagonist.(In Vitro):MRT-83 blocks BC binding to HEK-hSmo cells in a dose-dependent manner with an IC50 of 4.6 nM. MRT-83 abrogates BC binding to cells expressing mouse Smo with an IC50 of 14 nM, which is in good correlation with its IC50 in the Shh-light2 and alkaline phosphatase assays.(In Vivo): MRT-83 can't up-regulation of Ptc transcription in the SVZ of these animals in agreement with complete inhibition of ShhN-mediated effects (8.7±2.4 Ptc+ cells/section, n=9) and is not different from vehicle-mediated effects.
  • 体外实验
    MRT-83 displays full antagonist properties with an IC50 (~3 nM) for inhibiting ShhN (3 nM)-induced proliferation of rat GCPs. MRT-83 also blocks SAG (0.01 μM)-induced proliferation of GCPs (IC50 ~6 nM). MRT-83 blocks BC binding to HEK-hSmo cells in a dose-dependent manner with an IC50 of 4.6 nM. MRT-83 abrogates BC binding to cells expressing mouse Smo with an IC50 of 14 nM, which is in good correlation with its IC50 in the Shh-light2 and alkaline phosphatase assays.
  • 体内实验
    Animals treated with ShhN in the presence of MRT-83 are as healthy as those of the other groups but up-regulation of Ptc transcription in the SVZ of these animals is no longer observed in agreement with a complete inhibition of ShhN-mediated effects (8.7±2.4 Ptc+ cells/section, n=9) and is not different from vehicle-mediated effects. MRT-83 but not MRT-36 antagonizes the up-regulation of Ptc transcription induced by ShhN in vivo in the SVZ of the LV.
  • 同义词
    ——
  • 通路
    Wnt/Notch/Hedgehog
  • 靶点
    Smoothened (Smo)
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1263131-92-5
  • 分子量
    538.604
  • 分子式
    C31H30N4O5
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 250 mg/mL (464.17 mM)
  • SMILES
    COc1cc(cc(OC)c1OC)C(=O)NC(=N)Nc1ccc(C)c(NC(=O)c2ccc(cc2)-c2ccccc2)c1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Zhang, H., Sun, J., Xin, X., et al. Modulating self-assembly behavior of a salt-free peptide amphiphile (PA) and zwitterionic surfactant mixed system. J. Colloid. Interface Sci. 467, 43-50 (2016).
产品手册
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