MRT-81

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MRT-81 可有效抑制人类和啮齿动物的平滑 Smo 受体，在 Shh-light2 细胞中的 IC50 值为 41 nM。 MRT-81 具有有效的刺猬抑制活性。 MRT-81也可用于癌症研究。

MRT-81 inhibits human and rodent smoothened?Smo?receptors effectively with an IC50?value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cancer.(In Vitro):MRT-81 inhibits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatase positive osteoblasts induced by the Smo agonist SAG with 0.1 μM, with an IC50?value of 64 nM.

MRT-81 inbihits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatasepositive osteoblasts induced by the Smo agonist SAG (0.1 μM), with an IC50 value of 64 nM.MRT-81 (1-1000 nM) is a potent antagonist of SAG (0.01 μM)-induced proliferation of rat granule cell precursors (GCPs) with an IC50 less than 10 nM.MRT-81 (0, 0.1, 1, 10, 30, 100, 300, 1000 nM; 2 h; 37 °C) blocks BODIPY-cyclopamine (5 nM) binding to hSmo in a dose-dependent manner with an IC50 of 63 nM in HEK-hSmo cells.

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Others

Other Targets

hDHODH

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1263132-08-6

555.65

C31H29N3O5S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (179.97 mM)

COc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1ccc(C)c(NC(=O)c2ccc(cc2)-c2ccccc2)c1

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(-20℃)

With Ice Pack

≥ 2 years