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MN58b
CAS No. 203192-01-2
MN58b ( MN-58b | MN 58b )
产品货号. M13164 CAS No. 203192-01-2
MN58b 是一种有效的选择性胆碱激酶 α (ChoKα) 抑制剂，IC50 为 1.4 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥6148 | 有现货 |
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| 10MG | ￥7995 | 有现货 |
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| 25MG | ￥12555 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥22599 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MN58b
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MN58b 是一种有效的选择性胆碱激酶 α (ChoKα) 抑制剂，IC50 为 1.4 uM。
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产品描述MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM, >30-fold selectivity over ChoKβ and does not affect MAPKs, PI3Ks, and other enzymes involved in the regulation of phospholipid metabolism; demonstrates antiproliferative properties against human tumor-derived cell lines (HT29 IC50=0.5 uM) and antitumor activity against human tumor xenografts in vivo.
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体外实验Cell Viability Assay Cell Line:SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells Concentration:1 μM, 5 μM Incubation Time:72 hours Result:Inhibited cells growth.Apoptosis Analysis Cell Line:SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells Concentration:1 μM, 2 μM, 5 μM, 10 μM Incubation Time:24 and 48 hoursResult:Induced cell apoptosis.
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体内实验Animal Model:MF-1 nude mice with HT29 or MDA-MB-231 cells Dosage:4 mg/kg Administration:Intraperitoneal injection; once a day; for 5 daysResult:Phosphomonoesters decreased significantly.
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同义词MN-58b | MN 58b
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通路Others
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靶点ChoK
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受体ChoK
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研究领域——
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适应症——
化学信息
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CAS Number203192-01-2
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分子量640.508
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分子式C32H40Br2N4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 14.71 mg/mL (22.97 mM)
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SMILES——
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化学全称1,1'-((butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lacal JC, et al. Mol Cancer Ther. 2015 Jan;14(1):31-9.
2. Hernández-Alcoceba R, et al. Cancer Res. 1999 Jul 1;59(13):3112-8.
3. Al-Saffar NM, et al. Cancer Res. 2006 Jan 1;66(1):427-34.
4. Guma M, et al. Ann Rheum Dis. 2015 Jul;74(7):1399-407.
