sHNG, [Gly14] - HN, [Gly14] – Humanin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) 是 Humanin 的类似物，其中第 14 个氨基酸丝氨酸被甘氨酸 (Gly) 取代。(Gly14)-Humanin (human) 具有抗细胞凋亡和神经保护功能。

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.

(Gly14)-Humanin (human)（0.1 μg/5 μL；i.c.v.；一次）减少受损皮层和海马体中具有质膜通透性的细胞，减少脑损伤体积，改善运动性能并改善莫里斯水迷宫试验中的性能。Animal Model:Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI) Dosage:0.1 μg/5 μL Administration:Intracerebroventricularly (i.c.v.); once Result:Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.

(Gly14)-Humanin (human) (0.1-10 μM; 72 hours) 显着增加细胞活力，降低 HUVEC 的核荧光、裂解 PARP 水平、ROS 形成和 bax/bcl-2 比值 。并降低 bax 的mRNA水平，增加 bcl-2 的 mRNA 水平。Cell Viability Assay Cell Line:Human umbilical vein endothelial cells (HUVECs)，Concentration:100 nM, 1 μM and 10 μM Incubation Time:Pretreatment 3 hours and then treated with 72 hours Result:Significantly increased cell viability.Western Blot Analysis Cell Line:Human umbilical vein endothelial cells (HUVECs)，Concentration:1 μM Incubation Time:Pretreatment 3 hours and then treated with 72 hours Result:Reduced the ratio of bax/bcl-2.

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Others

Other Targets

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330936-70-4

2657.25

C118H202N34O31S2

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years