Hepcidin-1 (mouse) trifluoroacetate salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hepcidin-1 (mouse) 是一种参与铁稳态调节的内源性肽激素。Hepcidin-1 (mouse) 上调 TRAP、组织蛋白酶 K 和 MMP-9 的 mRNA 水平并增加 TRAP-5b 蛋白分泌。Hepcidin-1 (mouse) 下调 FPN1 蛋白水平并增加细胞内铁。Hepcidin-1 (mouse) 促进破骨细胞分化。

Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation.

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Hepcidin-1 mouse (200-800 nM，4 天) 促进 RANKL (50 ng/mL) 诱导的 raw264.7 细胞分化。Hepcidin-1 mouse (0-800 nM，4 天) 上调 TRAP、CTK 和 MMP-9 mRNA 的表达。Hepcidin-1 mouse (0-800 nM，20 小时) 会增加 RAW264.7 细胞中 Trap-5b 蛋白的水平并降低铁转运蛋白 1 (FPN1) 蛋白。Western Blot Analysis Cell Line:RAW264.7 cells Concentration:0, 200, 400, or 800 nM Incubation Time:20 h Result:Decreased Ferroportin 1 (FPN1) protein.Real Time qPCR Cell Line:RAW264.7 cells Concentration:0, 200, 400, or 800 nM Incubation Time:4 days Result:Increased the gene expression of TRAP, CTK, and MMP-9 in a dose-dependent manner.

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Others

Other Targets

MMP-9, cathepsin K

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1676104-75-8

2754.28

C111H169N31O35S8

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years