Secretin Acetate, porcine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Secretin (swine)，是一种神经内分泌激素，是第一个被识别的激素，主要由定位于十二指肠黏膜的 S 细胞分泌。Secretin 也是一个由 27 个氨基酸组成的多肽，作用于分泌素受体。Secretin 在所有成熟的肠内分泌细胞亚群中都有表达，并可由脂肪酸促进。Secretin 刺激胰腺水和碳酸氢盐的分泌。Secretin 在器官中发挥多种作用，可用于消化系统、中枢神经系统和能量代谢的研究。

Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.

Secretin (swine) (2.5 nM/kg, BW/day, osmotic minipumps, for 1 week) stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.Animal Model:Sct+/- mice Dosage:2.5 nM/kg Administration:2.5 nM/kg, BW/day, osmotic minipumps, for 1 week Result:Increased in supernatants from cholangiocytes and S cells and in serum and bile following BDL in control mice.Had low IBDM, reduced proliferation, and reduced production of vascular endothelial growth factor A (VEGFA) and nerve growth factor (NGF) in BDL Sct+/- mice. Regulated VEGF and NGF expression that negatively correlated with microRNA 125b and let7a levels in liver tissue.

Secretin (swine) (10-7M, 10-6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling.Secretin (10-7M, 10-6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines.Immunofluorescence Cell Line:large murine cholangiocyte lines Concentration:10?7M, 10?6 M Incubation Time:24 to 72 h and 7 days Result:Increased the proliferation of cholangiocytes.Cell Proliferation Assay Cell Line:human HIBEpiC and large murine cholangiocyte lines Concentration:10?7M, 10?6M Incubation Time:24 to 72 h and 7 days Result:Increased the proliferation of non-transfected, vector-transfected and secretin shRNA large cholangiocytes and HiBEpiC compared to the cell lines treated with BSA (basal).

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Others

Other Targets

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17034-35-4

3055.41

C130H220N44O41

>98% (HPLC)

DMSO : 66.67 mg/mL (21.82 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years