Swainsonine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Swainsonine (Tridolgosir) 是一种天然的吲哚里西啶生物碱，是一种有效且可逆的 α-甘露糖苷酶 （α-mannosidase） 抑制剂。Swainsonine 诱导细胞凋亡 （apoptosis）和细胞周期停滞在 G2/M 期。Swainsonine 具有抗肿瘤活性。

Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.

Swainsonine (1 mg/kg；腹腔注射；每天两次，持续 10 天) 和顺铂提高了小鼠的抗肿瘤功效。Animal Model:Eighty-seven sixty-day-old male C57BL/6 mice Dosage:1 mg/kg (cisplatin; 0.25 mg/kg, i.p., every other day for 10 days)Administration:I.p.; twice daily for ten days Result:Showed a significant reduction in ascites volume of 63.5% was observed in mice and a significant reduction in the percentage of cells in the G0/G1, S and G2 phases.

Swainsonine (0-40 μM；12 h) 在 U251 和 LN444 细胞中显示抗增殖活性。 Swainsonine (30 μM；12 h) 诱导细胞凋亡和细胞周期停滞在 G2/M 期，并降低 CyclinD1 和 CDK4 蛋白水平的表达，增加 p16 蛋白水平的表达。 Swainsonine (30 μM；12 h) 减少胶质瘤细胞迁移和侵袭。Cell Viability Assay Cell Line:U251, LN444 cells Concentration:0, 10, 20, 30, 40 μM Incubation Time:12 h Result:Inhibited cell viability in a dose-dependent manner, and shows no cytotoxicity in normal brain cells.Cell Cycle Analysis Cell Line:U251 cells Concentration:30 μM Incubation Time:12 h Result:Induced cell cycle arrest at G2/M phase.Apoptosis Analysis Cell Line:U251 cells Concentration:30 μM Incubation Time:12 h Result:Induced apoptosis with the cleaved-Caspase-3 and cleaved-Caspase-9 expression were obviously increased.

苦马豆素

Others

Other Targets

α-mannosidase

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72741-87-8

173.21

C8H15NO3

>98% (HPLC)

DMSO : 10 mg/mL (57.73 mM; ultraphonic; ) Ethanol : 10 mg/mL (57.73 mM; ultraphonic)

OC1CN2CCCC(O)C2C1O

OC1CN2CCCC(O)C2C1O

(-20℃)

With Ice Pack

≥ 2 years